No, its the same install of Windows. I used Driver Sweep in safe mode to erase the nVidia display drivers also.
I've figured out that it is the VPU Recover utility that is crashing the game. Every time I launch the game I can play for about 10 minutes before the screen goes blank and starts flickering randomly with colored boxes. After a minute or so of this it finally goes back to the desktop with the VPU message displayed.
Another Edit: I've disabled the VPU in the Catalyst Control Panel and this seems to have stopped the crashing. I'll be sure to update again later on if the problems persist.